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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Org Lett. 2016 Mar 21;18(7):1674–1677. doi: 10.1021/acs.orglett.6b00555

Table 6.

Cell Cytotoxicity (IC50, nM) of Ipomoeassin F Analogues 26 and 27a,b

MDA-MB-231 MCF7 HeLa U937 Jurkat MCF-10A NIH/3T3
ipomoeassin F 6.5 43.7 16.4 5.4 6.1 5.4 16.8
26 59.1 124 87.2 27.4 242 151 137
27 18.8 78.2 30.0 17.1 22.5 11.8 20.7
a

The data were obtained from at least two independent experiments, and the standard errors are within 20%.

b

MCF-10A and NIH/3T3 are two nontumor cell lines.