Skip to main content
. Author manuscript; available in PMC: 2016 Apr 5.
Published in final edited form as: Gastroenterology. 2014 Sep 3;147(6):1417–1428. doi: 10.1053/j.gastro.2014.08.042

Figure 5.

Figure 5

The proportion of DRG neurons responding to BAs and agonists of TRP channels. [Ca2+]i was measured in small diameter neurons from wild-type (WT) mice (A, F), WT mice in Ca2+-free medium (B), tgr5−/− mice (C), trpa1−/− mice (D), WT mice treated with the TRPA1 antagonist HC-030031 (E). They were challenged sequentially with AITC (100 μM), DCA (A–E) or TLCA (F) (both 100 μM), capsaicin (CAP, 1 μM), and finally KCl (50 mM). The proportion of small-diameter neurons that responded to the combinations of AITC, DCA or TLCA, and capsaicin are shown. Pooled data from 184–1435 neurons, n = 5–12 mice.