Generalization of comparative changes of FGAs and SGAs on physiological processes thought to be dysfunctional in schizophrenia. These comparative observations are based on either changes found in patients with schizophrenia or inferred from in vitro or animal studies cited in this review. In some instances, the effects of the drugs within the class differ, and this is denoted by the use of two symbols. NC, no change;+, increase or improvement; −, decrease or decline.