Fig. 1.

Electrophysiological heterogeneity in the anatomically-based model of the human ventricles in acute regional ischemia. A. Resting potential distribution with elevated potentials in ischemic tissue (green solid line), location of the pseudo-ECG probe (black asterisk) and ectopic stimulation site (magenta solid line). B. Action potential duration (APD) distribution highlighting APD shortening in the ischemic central zone (ICZ) (top) and examples of action potentials in normal zone (NZ), border zone (BZ) and ICZ from the locations marked with green dots in the APD map. C. Activation times distribution (top) and pseudo-ECG (bottom) exhibiting first the QRS complex, followed by a positive T wave (due to the inverse relationship between APD and activation times) and ischemia-induced ST elevation.