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. 2016 Mar 31;5:F1000 Faculty Rev-418. [Version 1] doi: 10.12688/f1000research.7796.1

Figure 2. T cell receptor-dependent transactivation of LFA-1.

Figure 2.

Diagram depicts the major interactions involved in actin-dependent T cell receptor (TCR) and integrin immobilization at the immune synapse (IS), including the signaling modules involved in LFA-1 transactivation. The diagram focuses on the role of SLP-76/ADAP/SKAP-55 in recruiting kindlin-3 and RIAM in proximity to integrin, and the role of Rap/RapL/RIAM in promoting talin association with the β chain of the LFA-1 dimer.