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Distortion of the vascular wall architecture in fibrotic areas. a/ Grade I lesions characterized by isolated hypertrophy of the arterial media. b/ Grade II lesions characterized by proliferative intimal cells. c/ Grade III lesions characterized by the total occlusion of the arterial lumen by fibrosis tissue. d/ Grade IV lesions characterized by plexiform lesions and major proliferation of elastic fibres in the internal and external elastic lumina of the vascular wall.
