Table 3. Allele and genotype frequencies of rs4795067, rs1799983 and rs1800779 in BD.
| SNPs | Genotype |
BD patients |
Controls |
P value | Pc value | OR(95%CI) |
|---|---|---|---|---|---|---|
| Allele | n(freq) | n(freq) | ||||
| NOS2/rs4795067 |
AA |
484(0.66) |
929(0.68) |
0.28 |
NS |
0.90(0.74–1.09) |
| |
AG |
231(0.32) |
400(0.29) |
0.32 |
NS |
1.10(0.91–1.34) |
| |
GG |
18(0.03) |
30(0.02) |
0.72 |
NS |
1.12(0.62–2.02) |
| |
A |
1199(0.82) |
2258(0.83) |
0.29 |
NS |
0.92(0.78–1.08) |
| |
G |
267(0.18) |
460(0.17) |
0.29 |
NS |
1.09(0.93–1.29) |
| NOS3/rs1799983 |
GG |
509(0.69) |
1027(0.76) |
2.5×10−3 |
0.02 |
0.74(0.60–0.90) |
| |
GT |
143(0.20) |
182(0.13) |
2.3×10−4 |
2.1×10−3 |
1.57(1.23–1.99) |
| |
TT |
81(0.11) |
150(0.11) |
0.99 |
NS |
1.00(0.75–1.33) |
| |
G |
1161(0.79) |
2236(0.82) |
0.02 |
NS |
0.82(0.70–0.96) |
| |
T |
305(0.21) |
482(0.18) |
0.02 |
NS |
1.22(1.04–1.43) |
| NOS3/rs1800779 |
AA |
658(0.90) |
1201(0.88) |
0.33 |
NS |
1.15(0.86–1.54) |
| |
AG |
67(0.09) |
150(0.11) |
0.18 |
NS |
0.81(0.60–1.10) |
| |
GG |
8(0.01) |
8(0.01) |
0.21 |
NS |
1.86(0.70–4.99) |
| |
A |
1383(0.94) |
2552(0.94) |
0.56 |
NS |
1.08(0.83–1.42) |
| G | 83(0.06) | 166(0.06) | 0.56 | NS | 0.92(0.70–1.21) |
Pc, Bonferroni corrected p value; OR, odds ratio; NS, not significant; SNP, single nucleotide polymorphism.