Table 5. Main effects of rs1799983 on clinical feature risk of BD,
| Clinical features | Genotype |
BD with |
BD without |
P value | Pc value | OR(95%CI) |
|---|---|---|---|---|---|---|
| Allele | n(freq) | n(freq) | ||||
| Genital ulcer |
|
n=410 |
n=323 |
|
|
|
| |
GG |
274(0.67) |
235(0.73) |
0.08 |
NS |
0.75 (0.55–1.04) |
| |
GT |
88(0.21) |
55(0.17) |
0.13 |
NS |
1.33 (0.92–1.94) |
| |
TT |
48(0.12) |
33(0.10) |
0.52 |
NS |
1.17 (0.73–1.86) |
| |
G allele |
636(0.78) |
525(0.81) |
0.08 |
NS |
0.80 (0.62–1.03) |
| |
T allele |
184(0.22) |
121(0.19) |
0.08 |
NS |
1.26 (0.97–1.62) |
| Skin lesions |
|
n=526 |
n=207 |
|
|
|
| |
GG |
361(0.69) |
148(0.71) |
0.45 |
NS |
0.87 (0.61–1.24) |
| |
GT |
102(0.19) |
41(0.20) |
0.90 |
NS |
0.97 (0.65–1.50) |
| |
TT |
63(0.12) |
18(0.09) |
0.20 |
NS |
1.43 (0.82–2.48) |
| |
G allele |
824(0.78) |
337(0.81) |
0.19 |
NS |
0.83 (0.62–1.10) |
| |
T allele |
228(0.22) |
77(0.19) |
0.19 |
NS |
1.21 (0.91–1.62) |
| Arthritis |
|
n=115 |
n=618 |
|
|
|
| |
GG |
86(0.75) |
423(0.68) |
0.18 |
NS |
1.37 (0.87–2.15) |
| |
GT |
19(0.16) |
124(0.20) |
0.38 |
NS |
0.79 (0.46–1.34) |
| |
TT |
10(0.09) |
71(0.12) |
0.77 |
NS |
0.90 (0.45–1.80) |
| |
G allele |
191(0.83) |
970(0.79) |
0.12 |
NS |
1.34 (0.93–1.95) |
| |
T allele |
39(0.17) |
266(0.22) |
0.12 |
NS |
0.75 (0.51–1.08) |
| Positive pathergy test |
|
n=167 |
n=566 |
|
|
|
| |
GG |
120(0.72) |
389(0.69) |
0.44 |
NS |
1.16 (0.79–1.70) |
| |
GT |
33(0.20) |
110(0.19) |
0.93 |
NS |
1.02 (0.66–1.58) |
| |
TT |
14(0.08) |
67(0.12) |
0.21 |
NS |
0.68 (0.37–1.25) |
| |
G allele |
273(0.82) |
888(0.78) |
0.19 |
NS |
1.23 (0.90–1.68) |
| |
T allele |
61(0.18) |
244(0.22) |
0.19 |
NS |
0.81 (0.60–1.11) |
| Retinal vasculitis |
|
n=40 |
n=693 |
|
|
|
| |
GG |
27(0.67) |
482(0.70) |
0.78 |
NS |
0.91 (0.46–1.80) |
| |
GT |
10(0.25) |
133(0.19) |
0.37 |
NS |
1.40 (0.67–2.94) |
| |
TT |
3(0.08) |
78(0.11) |
0.46 |
NS |
0.64 (0.19–2.12) |
| |
G allele |
64(0.80) |
1097(0.79) |
0.86 |
NS |
1.05 (0.80–1.85) |
| T allele | 16(0.20) | 289(0.21) | 0.86 | NS | 0.95 (0.54–1.67) |
Pc, Bonferroni corrected p value; OR, odds ratio; NS, not significant; SNP, single nucleotide polymorphism.