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. 2016 Feb 1;6(2):155–164. doi: 10.1002/2211-5463.12032

Figure 5.

Figure 5

YAP1 knockdown reduces cell proliferation and induces apoptosis in miR‐497 down‐regulating Huh7 cells. (A) Huh7 cells with anti‐miR‐497 vector transfection (Huh7‐anti‐miR‐497) that was transfected with scrambled siRNA and YAP1 siRNA, respectively, were subjected to western blot for YAP1 expression. n = three independent experiments, *P < 0.05 by t‐test. (B) Cell proliferation as measured by BrdU incorporation assays was inhibited by YAP1 knockdown in Huh7‐anti‐miR‐497 cells as compared with control cells. n = three repeats with similar results, *P < 0.05 by t‐test. (C) YAP1 down‐regulating Huh7‐anti‐miR‐497 cells conferred a large subgroup of apoptotic cells as compared with control cells. n = three repeats with similar results, *P < 0.05 by t‐test.