Table 1.

Clinical association analyses of miR‐497 expression in HCC

Clinicopathologic features	n = 86	miR‐497 expression		P
		Low	High
Age (year)
<50	25	14	11	0.476
≥50	61	29	32
Sex
Male	68	35	33	0.596
Female	18	8	10
HBV
Absent	24	10	14	0.336
Present	62	33	29
Serum AFP level (ng·mL−1)
<20	20	6	19	0.002*
≥20	66	37	24
Tumor size (cm)
<5	27	8	19	0.011*
≥5	59	35	24
No. of tumor nodules
1	60	29	31	0.639
≥2	26	14	12
Cirrhosis
Absent	31	13	18	0.261
Present	55	30	25
Venous infiltration
Absent	46	19	27	0.084
Present	40	24	16
Edmondson–Steiner grading
I + II	51	20	31	0.016*
III + IV	35	23	12
TNM tumor stage
I + II	67	28	39	0.004*
III + IV	19	15	4

HCC, hepatocellular carcinoma; HBV, hepatitis B virus; AFP, alpha‐fetoprotein; TNM, tumor–node–metastasis.

*Statistically significant.