Table 1. Patient characteristics, 21-OH antibody titers and HLA haplotypes.
21-OH antibody titers were classified as + (11 – 100), ++ (101 – 1,000) and +++ (1,001 – 10,000).
| Patient | Gender | Age at Diagnosis | Disease duration at sampling (years) | 21-OH Ab titre | HLA-A | HLA-B | HLA-C | HLA-DRB1 | HLA-DQB1 |
|---|---|---|---|---|---|---|---|---|---|
| Patient 1 | F | 59 | 0.5 | ++ | A*02 | B*07, B*15 | C*03, C*07 | DRB1*04, DRB1*09 | DQB1*03 |
| Patient 2 | F | 40 | 2 | ++ | A*01, A*03 | B*08, B*18 | C*05, C*07 | DRB1*03 | DQB1*02 |
| Patient 3 | F | 18 | 2 | ++ | A*01, A*32 | B*07, B*08 | C*07 | DRB1*03, DRB1*15 | DQB1*02, DQB1*06 |
| Patient 4 | F | 35 | 1 | ++ | A*01 | B*08 | C*07 | DRB1*03 | DQB1*02 |
| Patient 5 | F | 52 | 1 | ++ | A*01, A*02 | B*04, B*08 | C*03, C*07 | DRB1*03, DRB1*04 | DQB1*02 |
| Patient 6 | F | 23 | 1 | ++ | A*01, A*03 | B*04, B*08 | C*03, C*07 | DRB1*03, DRB1*04 | DQB1*02, DQB1*03 |
| Patient 7 | F | 17 | 1 | ++ | A*02, A*68 | B*08, B*44 | C*05, C*07 | DRB1*03, DRB1*15 | DQB1*02, DQB1*06 |
| Patient 8 | F | 18 | 2 | ND | A*01 | B*08, B*15 | C*07 | DRB1*03, DRB1*11 | DQB1*02, DQB1*03 |
| Patient 9 | M | 22 | 2 | ++ | A*01, A*03 | B*07, B*08 | C*07 | DRB1*03, DRB1*15 | DQB1*02, DQB1*06 |
| Patient 10 | F | 54 | 4 | ++ | A*01, A*24 | B*08, B*35 | C*04, C*07 | DRB1*03, DRB1*07 | DQB1*02, DQB1*03 |
| Patient 11 | F | 36 | 1 | ++ | A*02, A*26 | B*07, B*15 | C*03, C*07 | DRB1*03, DRB1*12 | DQB1*03 |
| Patient 12 | F | 56 | 1 | ++ | A*02 | B*08, B*15 | C*03, C*07 | DRB1*04 | DQB1*03 |
| Patient 13 | M | 25 | 3 | ++ | A*02, A*24 | B*27, B*44 | C*02, C*05 | DRB1*04 | DQB1*04, DQB1*05 |
| Patient 14 | M | 17 | 2 | +++ | A*01, A*03 | B*08, B*15 | C*03, C*07 | DRB1*08, DRB1*14 | DQB1*02, DQB1*04 |
| Patient 15 | M | 18 | 2 | + | A*01, A*02 | B*27, B*44 | C*02, C*05 | DRB1*03, DRB1*08 | DQB1*03, DQB1*06 |
| Patient 16 | F | 45 | 4.5 | + | A*32, A*66 | B*07, B*35 | C*04, C*07 | DRB1*04, DRB1*13 | DQB1*03, DQB1*05 |
| Patient 17 | F | 24 | 3.5 | +++ | A*02 | B*35, B*37 | C*02 | DRB1*04, DRB1*16 | DQB1*03, DQB1*05 |
| Patient 18 | F | 18 | 2 | ++ | A*01, A*02 | B*08, B*40 | C*07 | DRB1*04, DRB1*15 | DQB1*02, DQB1*03 |
| Patient 19 | F | 39 | 17 | ++ | A*01, A*02 | B*08, B*40 | C*03, C*07 | DRB1*03, DRB1*12 | DQB1*02, DQB1*06 |
| Patient 20 | F | 33 | 19 | ++ | A*31 | B*40, B*51 | C*03, C*15 | DRB1*03, DRB1*15 | DQB1*02, DQB1*03 |
| Control 1 | _ | _ | N/A | N/A | A*02, A*03 | B*07, B*44 | C*05, C*07 | DRB1*04, DRB1*15 | DQB1*03, DQB1*06 |
| Control 2 | _ | _ | N/A | N/A | A*02, A*29 | B*44 | C*05, C*16 | DRB1*07, DRB1*12 | DQB1*02, DQB1*03 |
| Control 3 | _ | _ | N/A | N/A | A*02, A*11 | B*44 | C*04, C*05 | DRB1*04, DRB1*13 | DQB1*03, DQB1*06 |
| Control 4 | _ | _ | N/A | N/A | A*02, A*03 | B*07, B*57 | C*06, C*07 | DRB1*07, DRB1*15 | DQB1*06 |
| Control 5 | _ | _ | N/A | N/A | A*02, A*32 | B*08, B*14 | C*07, C*08 | DRB1*03, DRB1*07 | DQB1*02 |
| Control 6 | _ | _ | N/A | N/A | A*23, A*25 | B*13,B*44 | C*05, C*06 | DRB1*04, DRB1*07 | DQB1*02, DQB1*03 |
| Control 7 | _ | _ | N/A | N/A | A*24 | B*07, B*35 | C*04, C*07 | DRB1*03, DRB1*13 | DQB1*02, DQB1*06 |