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. Author manuscript; available in PMC: 2016 Apr 5.
Published in final edited form as: Am J Psychiatry. 2015 Oct 16;173(1):44–52. doi: 10.1176/appi.ajp.2015.14101358

Table 2.

Microglial activity, as measured by PBR28 distribution volume ratio, is elevated in subjects at ultra high risk of psychosis (df=21 p=0.004) and patients with schizophrenia (df=21 p<0.001) in the total grey matter, frontal and temporal cortical regions of interest but not in control regions (the cerebellum and brainstem). The mean regional distribution volume ratios are shown for each group together with those for matched controls. The results of the ANCOVA covarying for age and translocator-protein genotype are shown for each case-matched control comparison

Mean Regional DVR of [11C]PBR28 Control Stdev Ultra high risk Stdev F P Cohen’s d Control Stdev Schizophrenia SD F p Cohen’s d
Total grey Matter 2.032 0.017 2.088 0.021 10.332 0.004 1.244 2.465 0.020 2.557 0.014 20.802 <0.001 1.769
Frontal lobe 2.000 0.038 2.087 0.026 5.339 0.030 0.894 2.489 0.037 2.606 0.025 9.883 0.005 1.245
Temporal lobe 1.914 0.041 2.001 0.028 4.417 0.047 0.829 2.282 0.065 2.518 0.044 13.089 0.001 1.430
Cerebellum 2.307 0.055 2.287 0.081 0.062 0.805 - 2.863 0.060 2.873 0.063 0.015 0.905 -
Brain stem 2.291 0.191 2.489 0.28 0.500 0.487 - 2.514 0.154 2.097 0.234 3.194 0.088 -