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. 2016 Apr 5;11(4):e0153080. doi: 10.1371/journal.pone.0153080

Fig 3. Anti-inflammatory and antinociceptive activities of TF.

Fig 3

Groups of KM male mice were pre-treated p.o. with normal saline (control 20 mL/kg), aspirin (Asp 75 mg/20 mL/kg), dexamethasone (Dex 3 mg/20 mL/kg) and total flavonoids (TF) extracts (TF-50: 50 mg/20 mL/kg; TF-100: 100 mg/20 mL/kg; and TF-200: 200 mg/20 mL/kg). One hour after the last drug dose, each group of mice were treated with xylene (a), carrageenan (b) and formalin (c). The licking time was recorded for the first five minutes and minute 15–30 after formalin was injected into the paw. The total time added these two phases. The data were shown as the mean ± SD (n = 10). *p < 0.05 and **p < 0.01 significantly different from the control group.