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. Author manuscript; available in PMC: 2017 Mar 28.
Published in final edited form as: Cancer Lett. 2016 Jan 12;372(2):192–200. doi: 10.1016/j.canlet.2015.12.011

Figure 4. Tumors formed by drug-resistant cells (Cl66-Dox and Cl66 Pac) show higher proliferation and angiogenesis in comparison with tumors formed by parent Cl66 cells.

Figure 4

A) Immunohistochemical analysis of Ki67 and CD31 in tumors formed by Cl66, Cl66-Dox and Cl66-Pac cells in BALB/c mice. B) Quantification of Ki67 in tumors. Five different areas positive for Ki67 were counted for each tumor section and mean ± SE were plotted. Cl66 vs Cl66-Dox p < 0.001, Cl66 vs Cl66-Pac p < 0.001 and Cl66-Pac vs Cl66-Dox p = 0.002. C) Quantification of CD31 in tumors. Five different areas positive for CD31 were counted for each tumor section and mean ± SE were plotted. Cl66 vs Cl66-Pac and Cl66-Dox vs Cl66-Pac p < 0.001.