Fig 3. Geniposide prevents the cytotoxicity of oligomeric Aβ1–42 in neurons.
A, Effects of geniposide on the cell viability in neurons. Cells were treated with the indicated doses of geniposide for 24 h, and the cell viability was determined with MTT. B, Effects of oligomeric Aβ1–42 on the cell viability in the primary cultured cortical neurons. After cells were treated with the indicated doses of Aβ1–42 for 24 h, the cell viability was determined with MTT. C, Geniposide increases the cell viability of neurons induced by Aβ1–42. Cells were pre-incubated with geniposide at 2.5–10 μM for 24h, and then exposed to oligomeric Aβ1–42 at 5.0 μM for 24 h in the presence and absence of geniposide. The cell viability was measured by MTT. NS: non significance. N = 6 per group of cells. Studies were repeated four times and data were expressed as means ± SEM of percentage of vehicle-treated cells.