Fig 1. Naringenin inhibits KO₂-induced overt pain-like behavior.

(a-c) Mice received naringenin (16.7, 50 and 150 mg/kg, po) treatment 1 h before ip injection of 1 mg of KO₂ or ipl injection of 30 μg of KO₂. The total number of writhings was evaluated 0–20 min after ip injection of KO₂. (b) The number of paw flinches and (c) time spent licking the paw were evaluated 0–30 min after ipl injection of KO₂. Results are mean ± SEM of 6 mice per group per experiment, and are representative of 2 independent experiments. *p< 0.05 vs. saline group, #p< 0.05 vs. KO₂ group. One-way ANOVA followed Tukey’s post hoc.