Fig 4. The anti-apoptotic effect of lentiviral transduction leads to acquired Rituximab tolerance.

(a) Reduced apoptosis rate in lentivirally transduced versus non-transduced OCI-Ly-7 cell. (b) Reduced level of apoptosis in transduced cells relative to nontransduced cells exposed to Rituximab for 48 hours. (c) Analysis of potential anti-apoptotic capacities of lentiviral transduction in response to a series of apoptosis-inducing stimuli, including Rituximab (RTX) in OCI-Ly-7 cells. The relative number of cells was used as a growth inhibition index showing the ratio of treated cells relative to the untreated control.