Table 2. Comparison between subjects who tested positive and those who tested negative for human adenovirus (HAdV), according to demographic, clinical, and laboratory variablesa.
| Characteristic | HAdV-negative N = 248 | HAdV-positive N = 61 | P value for comparison |
|---|---|---|---|
| n/N (%) | n/N (%) | ||
| Demographic and clinical presentation | |||
| Males (%) | 143/244 (58.6) | 29/60 (48.3) | 0.15 |
| Mean age ± SD, yrs | 4.3 ± 3.3 | 3.2 ± 2.5 | 0.01 |
| Presence of fever” (%) | 211/220 (95.9) | 56/58 (96.6) | 0.99 |
| High-grade fever° (%) | 124/220 (56.4) | 42/58 (72.4) | 0.03 |
| Respiratory rate, breaths/min | 37.0 ± 11.7 | 34.7 ± 9.9 | 0.41 |
| SpO2 in room air, mean % ± SD | 97.2 ± 2.4 | 97.8 ± 1.9 | 0.17 |
| Clinical findings | |||
| Cough | 180/236 (76.3) | 43/60 (71.7) | 0.46 |
| Rhonchi | 25/239 (10.5) | 2/61 (3.3) | 0.08 |
| Rales | 108/240 (45.0) | 21/61 (34.4) | 0.14 |
| Wheezes | 30/240 (12.5) | 0/61 (0.0) | 0.004 |
| Diagnosis | |||
| Upper respiratory tract infection | 111/248 (44.8) | 39/61 (63.9) | |
| Lower respiratory tract infection | 137/248 (55.2) | 22/61 (36.1) | 0.007 |
| Clinical outcome | |||
| Hospitalization rate, no.(%) | 139/248 (56.1) | 17/61 (27.9) | <0.001 |
| Drug use, no. (%) | |||
| Antibiotics | 225/248 (90.7) | 53/61 (86.9) | 0.37 |
| Antipyretics | 101/111 (91.0) | 43/46 (93.5) | 0.76 |
| Aerosol therapy | 48/111 (43.2) | 14/46 (30.4) | 0.14 |
| Absence from child care attendance | 6.1 ± 3.3 | 9.1 ± 7.0 | 0.07 |
| mean days ± SD | |||
| Similar illness within the households | 45/111 (40.5) | 16/48 (33.3) | 0.39 |
| Laboratory data | |||
| White blood cell count (cells/μL) | 14,589 ± 8,255 | 15,381 ± 7,461 | 0.40 |
| Neutrophils, % | 63.4 ± 19.9 | 60.3 ± 17.0 | 0.27 |
| CRP, μg/dL | 12.2 ± 25.8 | 23.3 ± 53.9 | 0.40 |
CRP, C reactive protein; SD, standard deviation; SpO2, peripheral oxygen saturation.”38.0°C or more any time during the illness (before or at enrolment, or during follow-up); °39.0°C or more any time during the illness (before or at enrollment or during follow-up).
a Data were extracted from datasets of different studies that collected different information; therefore, the denominators vary across characteristics. However, when not indicated the reported number refers to the whole enrolled sample.