Table 6. Risk estimates from meta-analyses: comparison of original estimates with post-assessment estimates for the systematic review by Loke et al. [17].
| Outcome | Original Effect Estimate (95% CI) | Post-Assessment Effect Estimate (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|
| n | Cohort Studies | Case–Control Studies | Overall | n | Cohort Studies | Case–Control Studies | Overall | |
| Analysis A | ||||||||
| Myocardial infarction | 15 | 1.16 (1.05–1.28) | 1.15 (1.04–1.27) | 1.16 (1.07–1.24) | 10 | 1.10 (1.02–1.20) | 1.21 (1.01–1.45) | 1.12 (1.04–1.20) |
| Heart failure | 8 | 1.22 (1.15–1.29) | 1.39 (1.21–1.60) | 1.24 (1.16–1.31) | 6 | 1.21 (1.15–1.27) | No change | 1.21 (1.14–1.30) |
| Overall mortality | 8 | 1.14 (1.09–1.20) | 1.13 (0.92–1.39) | 1.14 (1.09–1.20) | 6 | No change | No change | No change |
| Analysis B | ||||||||
| Myocardial infarction | 15 | 1.16 (1.05–1.28) | 1.15 (1.04–1.27) | 1.16 (1.07–1.24) | 6 | 1.06 (0.99–1.13) | 1.00 (0.67–1.49) | 1.06 (0.99–1.13) |
| Heart failure | 8 | 1.22 (1.15–1.29) | 1.39 (1.21–1.60) | 1.22 (1.14–1.31) | 4 | 1.22 (1.16–1.28) | N/A | 1.22 (1.16–1.28) |
| Overall mortality | 8 | 1.14 (1.09–1.20) | 1.13 (0.92–1.39) | 1.14 (1.09–1.20) | 4 | 1.13 (1.08–1.20) | N/A | 1.13 (1.08–1.20) |
Analysis A: studies judged to have serious or critical overall RoB were excluded; analysis B: studies scoring moderate, serious, or critical RoB were excluded; n: number of studies included.
N/A, not applicable.