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. Author manuscript; available in PMC: 2017 May 15.
Published in final edited form as: Behav Brain Res. 2016 Feb 22;305:87–99. doi: 10.1016/j.bbr.2016.02.022

Fig. 5.

Fig. 5

Effects of Pramipexole on Pavlovian conditioned approach behavior. Following seven sessions of Pavlovian conditioning animals were classified as STs (n=12) or GTs (n=21) based on their propensity to approach the lever or food cup during the CS period. STs and GTs were then split into balanced treatment groups based on PCA Index score, with one group receiving vehicle (ST n=5; GT n=11) and the others receiving descending doses (0.32, 0.1, 0.032 mg/kg) of pramipexole (ST n=7; GT n=10) over the next three sessions (shaded region). On session 11 all rats were tested without vehicle or drug treatment. Pramipexole attenuated lever-directed behaviors in animals previously classified as STs (a–b) and food cup-directed behavior only in animals previously classified as GTs (c–d). Error bars indicate SEM