Table 3.

Seizure Frequency During the 2-Year Study Period and Participant Disposition

	No. of Seizures by 3-mo Intervala									Event, mo
Participants	Baseline	1–3	4–6	7–9	10–12	13–15	16–18	19–21	22–24	Withdrawal	Surgery
Medical group (n = 23)
101	9	10	21	10	9	2	0	2	0
109	3	7	1	0	2	1	0	0	0		15
113	15	12	16	10	13	7	19	28	18
145	21	0	0	4	6	9	5	14	5
157	3	5	4	2	2					17
173	3	90	31	9						12	12
185	4	15	16	10	15	14	8	0	0		18
189	6	4	0	0	2	0	8	4	1		22
191	21	1	0	1	0	5	3	0	0
205	9	2	8	6	1	2	0	0	0
207	9	2	0	0	0	2	1	3	1
209	6	33	46	65	52	40	104	137	97
221	15	58	121	136	153	214	179	1	20		17
237	63	18	14	4	9	12	4	212	7
253	21	11	22	22	17	11	6	0	0		16
257	36	20	40	24	26	18	21	16	13
273	12	12	4	1	0	1	0	0	2
285	30	10	24	24	10					10
321	4	25	8	0	1	1	0	2	5	22	5
338	15	13	13	3	4	13	13	7	9
350	9	1	29	2	2	1	2	3	0
352										3
381	9	0	2	0	0	0	1	0	2
Surgical group (n = 15)
110	6	1	1	1	1	0	4	3	1
114	6	0	0	0	0	0	0	0	0
190	32									2
206	3	0	0	0	0	0	0	0	0
225b	9	0	1	4	2	0	0	0			5c
258	279	4	0	0	0	0	0	0	0
259	6	0	0	0	0	0	1	2	3
269	3	0	0	0	0	0	0	0	0
317	5	0	0	0	0	0	0	0	0
333	3	0	0	0	0	0	0	0	0
337	6	0	0	0	0	0	0	0	0
349	10	0	0	0	0	0	0	0	0
351	84	0	0	0	0	0	0	0	0
382	9	0	0	0	0	0	0	0	0
417	3	2	0	0	0	0	0	0	0

^aValues are counts of disabling seizures over each 3-month period, with the time origin being randomization for the medical group and surgery for the surgical group. Unshaded table cells showing a value of zero indicate no seizures; cells shaded in gray indicate 1 to 4 seizures per month; cells shaded in blue indicate more than 4 seizures per month; and empty cells indicate no data collected on the seizure log.

^bParticipant 225 had surgery delayed until month 5 and consequently was not observed for 2 full years after surgery.

^cIndicates a late surgery.