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. 2016 Mar 7;213(4):535–553. doi: 10.1084/jem.20151100

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© 2016 Tang et al.

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Figure 6. DR selectively inhibits proliferation of lymphoid progenitors. (A–E) Mice were treated with DR or AL for 6 d. On day 4, a single dose of 180 µg BrdU was injected intraperitoneally, and the mice were continuously supplied with 0.8 mg/ml BrdU in drinking water for the subsequent 2 d (n = 5 mice per group; n = 2 independent experiments). Percentage (A) and absolute number (B) of BrdU− cells in the fraction of CLPs. Percentage (C) and absolute number (D) of BrdU+ cells in the fraction of CLPs. Unpaired two-tailed Student’s t test was used. (E) Representative FACS plots gated from CLPs. (F–J) Cell cycle activity analysis of CLPs (F), MEPs (H), GMPs (I), and CMPs (J) in mice treated with DR or AL for 3 wk or refed for 3 d after 3 wk of DR (n = 4–5 mice per group; n = 2 independent experiments). One-way ANOVA analysis was used. (G) Representative FACS plots gated from CLPs. Data are displayed as mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. ns, not significant. — DR selectively inhibits proliferation of lymphoid progenitors. (A–E) Mice were treated with DR or AL for 6 d. On day 4, a single dose of 180 µg BrdU was injected intraperitoneally, and the mice were continuously supplied with 0.8 mg/ml BrdU in drinking water for the subsequent 2 d (n = 5 mice per group; n = 2 independent experiments). Percentage (A) and absolute number (B) of BrdU⁻ cells in the fraction of CLPs. Percentage (C) and absolute number (D) of BrdU⁺ cells in the fraction of CLPs. Unpaired two-tailed Student’s t test was used. (E) Representative FACS plots gated from CLPs. (F–J) Cell cycle activity analysis of CLPs (F), MEPs (H), GMPs (I), and CMPs (J) in mice treated with DR or AL for 3 wk or refed for 3 d after 3 wk of DR (n = 4–5 mice per group; n = 2 independent experiments). One-way ANOVA analysis was used. (G) Representative FACS plots gated from CLPs. Data are displayed as mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. ns, not significant.