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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Neuroscientist. 2015 Jan 27;22(2):132–144. doi: 10.1177/1073858414568122

Figure 5.

Figure 5

Interaction between positive modulators of NMDAR activity and NMDAR channel blockers. A–C. Effects of the 24S-HC analogue SGE-201 on neuronal activity can be accounted for by effects on NMDAR activity. A, B Raster plots of action potential activity in a dissociated hippocampal culture on a multi-electrode array. The y axis represents the electrodes. C. Under baseline conditions SGE-201 increases spiking activity (ASDR) by >2 fold (blue bar), but no significant increase occurs in the presence of 20 μM MK-801 (open bar), an NMDAR antagonist. D–G. In the presence of positive modulator, the open-channel blockers memantine and ketamine reduce activity. G. Summary data showing that in the absence of SGE-201 (Control), the reduction in activity by the two channel blockers is indistinguishable. In the presence of SGE-201, the effect of the more voltage-sensitive compound memantine is relieved more than that of ketamine. Figure is adapted from (Emnett and others 2014) and used with permission.