Expression of ER targets involved in the IGF signaling pathway analyzed by PCR array in the ovarian tissue, n=6. A, mRNA expression of IGFBP4 decreased with whole flaxseed supplemented diet, defatted flax meal supplemented diet and flax oil supplemented diet, control vs. whole flax (p<0.05), control vs. whole flax (p<0.05), control vs. flax oil (p<0.05). B, mRNA expression of IGFBP5 decreased with whole flaxseed supplemented diet (p<0.05) C, mRNA expression of IRS1 decreased with diets supplemented with whole flaxseed and flax oil (p<0.05). Letters on the error bar shared among groups indicate no significant difference.