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Validation of Rac1 and Rac2 biosensors in macrophages. A) Ratiometric images of transiently overexpressed constitutively active (G12V) or dominant negative (T17N) Rac1 and B) Rac2 biosensor (with mcp229Ven) in RAW/LR5 cells. Scale bar = 10 μm. Bar graphs are quantitation of whole cell levels of Rac activity, n = at least 15 cells/condition, mean +/− SEM, p < 0.00001.
