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Summary of results for rolipram formulations that were tested in vivo.
| Formulation1 | In vitro release at 4 h | Maximum inhibition of airway hyperreactivity | Maximum inhibition of pulmonary edema |
|---|---|---|---|
| 100% rolipram | 70% | 100% | Not significant |
| 40% rolipram/60% PLGA | 36% | 100% | 48% |
| 40% rolipram/55% PLGA/5% PEG | 56% | 100% | Not significant |
All generated by spray drying of methylene chlorine solutions using 0.4 mm nozzle; PLGA formulations contain 50:50 ratio of lactide:glycolide.
