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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Thromb Res. 2015 Nov 19;140:132–139. doi: 10.1016/j.thromres.2015.11.023

Figure 5. Regulation of clot lysis by TM-dependent activation of TAFI in FIX-DP.

Figure 5

TM promotes inhibition of FL. (A) TG curves demonstrate negligible effect of TM on TG. Black curves: TM, 6.25 nM. Red curves: no TM. (B) FG/FL in the presence of TM (black) are more resilient to lysis than clots in the absence of TM (red). (B) Experiments were performed in FIX-DP supplemented with 0.15 μg/ml tPA, 130 μg/ml CTI, and 0 or 6.25 μg/ml TM. Means and S.D. (2 wells) is shown. Note that lysis resistance in the presence of TM occurs at TF concentrations where TG parameters are constant, see supplemental Fig. S6.