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Kinetic parameters for metabolism of 20(OH)D3 and its primary products by CYP3A4. Data for Km and kcat are presented as mean ± standard error of the curve fit.
| Substrate | Km (μM) | kcat (min−1) | kcat / Km (μM−1 min−1) |
|---|---|---|---|
| 20(OH)D3 | 32.6 ± 2.8 | 17.7 ± 0.5 | 0.54 |
| 20,24R(OH)2D3 | 331.8 ± 193.9 | 65.0 ± 28.5 | 0.20 |
| 20,24S(OH)2D3 | 86.9 ± 44.3 | 16.5 ± 4.3 | 0.19 |
