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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2016 Mar 9;159:131–141. doi: 10.1016/j.jsbmb.2016.03.014

Table 2.

Kinetic parameters for metabolism of 20(OH)D3 and its primary products by CYP3A4. Data for Km and kcat are presented as mean ± standard error of the curve fit.

Substrate Km (μM) kcat (min−1) kcat / Km (μM−1 min−1)
20(OH)D3 32.6 ± 2.8 17.7 ± 0.5 0.54
20,24R(OH)2D3 331.8 ± 193.9 65.0 ± 28.5 0.20
20,24S(OH)2D3 86.9 ± 44.3 16.5 ± 4.3 0.19