Table 1.
Statistical data in detecting the dose dependent effects of ketamine on the proliferation of the cortex of the developing brain using BrdU incorporation assay.
| Dose (mg kg-1) | vehicle | 1 | 2 | 10 | 20 | 40 | 100 |
|---|---|---|---|---|---|---|---|
| Total | 2860 ± 175 n=6 |
2744 ± 102 n=6 P=0.18 |
2705 ± 125 n=6 P=0.11 |
2690 ± 82 n=6 P=0.055 |
2586 ± 122 n=6 P=0.0004 |
2426 ± 107 n=6 P=0.0004 |
2136 ± 130 n=6 P<0.001 |
| VZ | 1569 ± 93 n=6 |
1532 ± 86 n=6 P=0.50 |
1531 ± 56 n=6 P=0.41 |
1550 ± 63 n=6 P=0.68 |
1431 ± 63 n=6 P=0.013 |
1365 ± 41 n=6 P=0.0006 |
1220 ± 58 n=6 P<0.001 |
| SVZ | 1291 ± 88 n=6 |
1212 ± 56 n=6 P=0.092 |
1174 ± 91 n=6 P=0.046 |
1140 ± 52 n=6 P=0.0047 |
1155 ± 77 n=6 P=0.016 |
1061 ± 91 n=6 P=0.0012 |
916 ± 88 n=6 P<0.001 |
Notes: data are shown as mean ± SD. Six embryonic brains in each ketamine dose group were used for the statistical analysis (n=6). P-values are calculated using t-test by comparing with the vehicle group. Significant difference is set at P < 0.05. Bolded numbers in the table indicate the significant difference compared with vehicle group data. Total: the sum of the numbers of BrdU positive cells at VZ and SVZ.