Table 1.
Anatomical, antigenic, and neurophysiological properties of V-SVZ cells.
| Type | Subtype | Morphology | Location | Markers | Glutamate related marker |
GABA related marker |
|
|---|---|---|---|---|---|---|---|
| V-SVZ astrocytes |
Type B1 | Overall Type B1 |
fusiform | Attached to the ventricle and blood vessels Cell body in V-SVZ |
GFAP + CD133 +/− Nestin +/− C×43 ; C×30 hgfap-GFP BLBP +/− |
GLAST GLT-1 VGlut1 Glutamate mGluR1-5 |
GAT4 GABAAR |
| quiescent | " | " | GFAP +; CD133 +/− |
? | ? | ||
| activated | " | " | GFAP +; Nestin + EGFR +; CD133 + hgfap-GFP BLBP |
? | ? | ||
| Type B2 | Intermediate fusiform /stellate |
Periphery of the V-SVZ, not in contact with the ependymal layer |
GFAP +; BLBP + Nestin +; C×43 +; Cx30? hgfap-GFP |
GLAST; GLT-1 VGlut1 ? Glutamate mGluR1-5 ? |
GAT4 GABAAR | ||
| Other astrocytes | Stellate | no specific location | hgfap-GFP +/− S100B +; GFAP? C×43 ? ; C×30? |
? | ? | ||
| Type C | Larger, more spherical than type B |
Core SVZ | Mash1 +; EGFR + Lex +; Dl×2 + BLBP+/− |
? | ? | ||
| Type A | bipolar elongated | Core SVZ | DCX +; Tuj 1 + PSA-NCAM + |
NMDA-R Kainate-R AMPA-R mGluR |
GAT1 VGAT GABAAR GABA |
||
| Ependymal cells | cubic | border of the ventricle | S100B +; CD24 + Nestin +; C×43+ CD133 (cilia) + |
- | - | ||
+/− indicates that the marker is not expressed in all the population