Table 2.
AMH and hCG detected or clinical loss among women with hCG or clinical or detected pregnancy stratified by reproductive history
| hCG detected Loss | Clinical Loss | |||||
|---|---|---|---|---|---|---|
| Low AMH <1.0 ng/ml | Normal AMH 1.0-3.5 ng/ml | High AMH >3.5 ng/ml | Low AMH <1.0 ng/ml | Normal AMH 1.0-3.5 ng/ml | High AMH >3.5 ng/ml | |
| Overall, Experienced loss-no (%) | 5 (4.0) | 27 (4.5) | 23 (4.8) | 19 (15.3) | 61 (10.3) | 50 (10.4) |
| RR, Unadj. | 0.95 (0.47,1.94) | Ref | 0.95 (0.59,1.53) | 1.32 (0.87,2.01) | Ref | 1.03 (0.76,1.4) |
| RR, *Adj. Model 1 | 0.89 (0.42,1.86) | Ref | 0.99 (0.61,1.61) | 1.17 (0.77,1.79) | Ref | 1.1 (0.80,1.49) |
| RR, †Adj. Model 2 | 0.90 (0.42,1.91) | Ref | 0.99 (0.55,1.79) | 1.13 (0.74,1.72) | Ref | 1.13 (0.82,1.56) |
| History of no previous live births (n=561), Experienced a loss - no. (%) | 3 (6.1) | 12 (5.4) | 13 (6.1) | 5 (10.2) | 26 (11.7) | 28 (13.2) |
| RR, Unadj. | 0.59 (0.19,1.79) | Ref | 0.99 (0.55,1.79) | 1.29 (0.76,2.18) | Ref | 1.02 (0.69,1.5) |
| RR, *Adj. Model 1 | 0.48 (0.16,1.49) | Ref | 1.08 (0.60,1.96) | 1.13 (0.66,1.93) | Ref | 1.06 (0.72,1.57) |
| RR, ††Adj. Model 2 | 0.47 (0.15,1.47) | Ref | 1.09 (0.61,1.97) | 1.14 (0.66,1.96) | Ref | 1.09 (0.73,1.61) |
| History of live birth (n=641), Experienced a loss - no. (%) | 2 (3.3) | 15 (4.9) | 10 (4.7) | 14 (23.3) | 35 (11.3) | 22 (10.4) |
| RR, Unadj. | 1.59 (0.62,4.08) | Ref | 1.09 (0.6,1.98) | 1.4 (0.73,2.7) | Ref | 1.09 (0.66,1.77) |
| RR, *Adj. Model 1 | 1.72 (0.66,4.48) | Ref | 0.81 (0.34,1.96) | 1.27 (0.65,2.5) | Ref | 1.17 (0.7,1.97) |
| RR, ††Adj. Model 2 | 0.94 (0.35,2.47) | Ref | 1.2 (0.64,2.22) | 1.47 (0.75,2.87) | Ref | 1.16 (0.69,1.94) |
| History of one previous loss (n=804), Experienced a loss - no. (%) | 2 (2.7) | 16 (5.0) | 16 (5.6) | 12 (16.0) | 37 (10.5) | 31 (10.8) |
| RR, Unadj. | 1.19 (0.77,1.85) | Ref | 0.90 (0.62,1.29) | 0.83 (0.38,1.82) | Ref | 1.06 (0.70,1.62) |
| RR, *Adj. Model 1 | 1.1 (0.46,2.65) | Ref | 0.87 (0.46,1.65) | 0.79 (0.35,177) | Ref | 1.09 (0.71,1.66) |
| RR, ††Adj. Model 2 | 0.89 (0.35,2.24) | Ref | 0.97 (0.5,1.88) | 0.80 (0.36,1.81) | Ref | 1.13 (0.71,1.79) |
| History of two previous losses (n=398), Experienced a loss - no. (%) | 3 (8.8) | 11 (6.1) | 7 (5.2) | 7 (20.6) | 24 (13.3) | 19 (14.0) |
| RR, Unadj. | 0.89 (0.35,2.28) | Ref | 0.96 (0.49,1.88) | 1.83 (1.12,2.99) | Ref | 0.90 (0.58,1.38) |
| RR *Adj. Model 1 | 0.73 (0.21,2.59) | Ref | 0.99 (0.49,1.98) | 1.43 (0.87,2.35) | Ref | 1.00 (0.65,1.54) |
| RR, ††Adj. Model 2 | 0.74 (0.21,2.66) | Ref | 0.98 (0.49,1.98) | 1.40 (0.85,2.3) | Ref | 0.98 (0.64,1.50) |
| Last loss within prior one year (n=946), Experienced a loss - no. (%) | 2 (13.3) | 8 (7.4) | 3 (4.0) | 3 (20.0) | 13 (12.0) | 6 (7.9) |
| RR, Unadj. | 0.79 (0.24,2.62) | Ref | 1.02 (0.51,2.04) | 1.33 (0.82,2.16) | Ref | 1.15 (0.82,1.62) |
| RR, *Adj. Model 1 | 0.76 (0.28,2.03) | Ref | 1.11 (0.64,1.91) | 1.24 (0.77,2.01) | Ref | 1.2 (0.85,1.68) |
| RR, ††Adj. Model 2 | 0.83 (0.30,2.27) | Ref | 1.05 (0.61,1.83) | 1.26 (0.78,2.03) | Ref | 1.22 (0.87,1.71) |
| Last loss ≥ one year prior (n=237), Experienced a loss - no. (%) | 3 (3.2) | 18 (4.4) | 20 (5.9) | 3 (20.0) | 13 (12.0) | 6 (7.90) |
| RR, Unadj. | 0.84 (0.30,2.31) | Ref | 1.06 (0.61,1.84) | 1.36 (0.63,2.93) | Ref | 0.68 (0.30,1.55) |
| RR, *Adj. Model 1 | 1.42 (0.49,4.11) | Ref | 0.63 (0.22,1.79) | 0.92 (0.39,2.17) | Ref | 0.78 (0.36,1.69) |
| RR, ††Adj. Model 2 | 0.79 (0.27,2.30) | Ref | 0.82 (0.3,2.28) | 0.8 (0.35,1.85) | Ref | 0.88 (0.43,1.80) |
Relative Risk (RR) presented as estimate (95% confidence interval).
*
Adjusted for age
†
Adjusted for age, race, BMI, treatment, income, parity, number of previous losses, recency of loss
††
Adjusted for age, race, BMI, treatment, income.