Left, activated SCs, when embedded in a myoconductive 3D environment, will rapidly fuse. Middle, a subset of the cells will home to the membrane of the developing myotubes, link to M-cadherin, and cease to proliferate. Right, with time, the SCs will further build their niche on the mature myofiber by homing beneath the basal lamina, expressing M-cadherin, and becoming quiescent.