Table 5. Associations (P<0.05) between DNA methylation of CpG sites in KLF14, FHL2 and GNPNAT1, and lower risk for future T2D in the Botnia prospective cohort.
| CpG site | Hazard-ratio (95% CI) | P value |
|---|---|---|
| CpG 1 (KLF14) | 0.88 (0.78-0.99) | 0.03 |
| CpG 2 (FHL2) | 0.94 (0.88-0.99) | 0.037 |
| CpG 3 (FHL2) | 0.92 (0.84-0.99) | 0.049 |
| CpG 5 (FHL2) | 0.82 (0.68-0.99) | 0.037 |
| cg16764848 (GNPNAT1) | 0.92 (0.88-0.96) | 8.0 × 10−5 |
| CpG 1 (GNPNAT1) | 0.94 (0.90-0.98) | 0.003 |
CI, confidence interval.
The association analyses were adjusted for age, sex, body mass index (BMI), HbA1c at baseline and family.