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. 2016 Apr 4;7:11157. doi: 10.1038/ncomms11157

Figure 3. Hierarchical clustering analysis of Panel 1 and Panel 2 odorants.

Figure 3

(a) Panel 1 odorants clustered according to chemical similarity as evaluated by 1,666 molecular descriptors downloaded through the e-dragon applet. (b) Panel 1 odorants clustered according to biological response similarity based on calcium imaging of dissociated OSNs. Note that in the chemical-based clustering the major division is on ring size while in the biological-based clustering the major division is on the TPSA. (c) Panel 2 odorants clustered according to their biological responses, as in b. Although there is a major division based on the presence of a double-ring scaffold, within each branch further subdivisions follow the TPSA rule as in b. *Cophenetic correlation coefficient. All distances in the dendrograms are Euclidian. See online methods for details of dendrogram generation.