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. 2016 Apr 4;7:11169. doi: 10.1038/ncomms11169

Figure 6. Schematic representation of mechanisms by which miR-192 mediates its anti-angiogenic function.

Figure 6

On the basis of findings described in the manuscript, TWIST1 downregulates miR-192 levels in cancer cells, leading to increased HOXB9 and EGR1 levels. These two transcription factors, in turn, lead to increased levels of multiple pro-angiogenic factors and increased tumour angiogenesis. Systemic delivery of miR-192 using DOPC nanoliposomes represents a potent means of blocking tumour angiogenesis and reducing tumour growth.