Table 4. Logistic models and related PCA results.

	Intercept	Colon				Intercept	Rectal
		Comp. 1a	Comp. 2	Comp. 3			Comp. 1a	Comp. 3	Comp. 4
Logistic model
Est. coefficient	1.19	−1.40	−1.09	−1.95	Est. coefficient	3.07	−2.90	−1.32	0.95
S.e.	0.46	0.27	0.28	0.48	S.e.	0.83	0.54	0.46	0.43
P-value	0.01	<0.001	<0.001	<0.001	P-value	<0.001	<0.001	<0.01	0.03
Corresponding PCA resultsb
% of sample var.		38.24	24.86	13.30	% of Sample var.		44.66	8.67	6.56
Included miRNA		Loadings			Included miRNA		Loadings
Hsa-miR-663b		−0.08	−0.07	−0.62	Hsa-miR-663b		−0.23	−0.36	−0.30
Hsa-miR-4539		0.26	0.25	−0.23	Hsa-miR-17-5p		−0.31	−0.08	0.07
Hsa-miR-17-5p		−0.38	0.09	−0.09	Hsa-miR-4323		0.24	−0.40	0.30
Hsa-miR-20a-5p		−0.37	0.10	−0.08	Hsa-miR-20a-5p		−0.30	−0.08	0.10
Hsa-miR-663a		0.04	0.01	−0.62	Hsa-miR-378a-3p		0.20	−0.12	−0.39
Hsa-miR-4538		0.26	0.26	−0.16	Hsa-miR-93-5p		−0.30	−0.04	−0.01
Hsa-miR-21-5p		−0.33	0.14	0.00	Hsa-miR-4539		0.28	−0.30	−0.01
Hsa-miR-215		−0.08	0.42	0.18	Hsa-miR-378i		0.19	−0.12	−0.39
Hsa-miR-4506		−0.20	−0.22	0.04	Hsa-miR-21-5p		−0.26	0.12	0.35
Hsa-miR-92a-3p		−0.33	0.13	−0.12	Hsa-miR-92a-3p		−0.29	−0.12	0.13
Hsa-miR-93-5p		−0.36	0.11	−0.02	Hsa-miR-145-5p		0.10	0.29	0.07
Hsa-miR-192-5p		−0.10	0.42	0.17	Hsa-miR-150-5p		0.15	0.21	−0.14
Hsa-miR-145-5p		−0.02	0.26	0.18	Hsa-miR-3651		−0.26	−0.15	0.09
Hsa-miR-3651		−0.33	0.11	−0.12	Hsa-miR-4749-3p		0.25	−0.30	0.31
Hsa-miR-378a-3p		0.17	0.41	−0.08	Hsa-miR-4506		−0.24	0.27	−0.39
Hsa-miR-378i		0.17	0.39	−0.09	Hsa-miR-424-3p		−0.24	−0.22	−0.05
—		—	—	—	Hsa-miR-6073		0.15	0.42	0.27

AIC, Akaike information criterion; miRNA, microRNA; PCA, principal component analysis.

^aThe components listed are those included in the model; model selection was based on AIC statistics.

^bLoadings and % of sample variance refer to the component listed in the corresponding column.