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. 2016 Apr 6;6:23748. doi: 10.1038/srep23748

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(A) Schematic of the regulatory domain (brown), catalytic domain (green) and tetramerization domain (pink) of the human PAH polypeptide. (B) DSF of the unliganded (grey line; Tm = 54.5 °C ± 0.01 SD) and Phe-bound (pink line; Tm = 75.2 °C ± 0.2 SD) hPAH-RD^1–118. (C) DSF of the unliganded (grey line; Tm = 62.1 °C ± 0.02 SD) and Phe-bound (pink line; Tm = 73.3 °C ± 0.1 SD) hPAH-RD^19–118.