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. 2016 Apr 6;6:23748. doi: 10.1038/srep23748

Figure 4. A phenylalanine binding mutation disrupts the propensity of hPAH-RD to homodimerize.

Figure 4

(A) DSF of the unliganded (grey line; Tm = 49.8 °C ± 0.2 SD)) and Phe-bound (pink line; Tm = 53.0 °C ± 0.03 SD) hPAH-RD p.E76A. (B) SEC-MALS of unliganded (grey line) and Phe-bound (pink line) of PAH-RD p.E76A.