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. Author manuscript; available in PMC: 2017 Feb 1.

Published in final edited form as: Am J Transplant. 2015 Oct 5;16(2):550–564. doi: 10.1111/ajt.13469

(A) CD4⁺ T cells to increase frequency of T_Naïve cells and reduce the frequency of T_EM cells during repopulation; however, this did not reach statistical significance when compared with baseline proportions. In contrast, CD8⁺ reconstitution contained increased in T_Naïve and decreased in T_EM and T_EMRA cell percentages. (B) Patients treated with alemtuzumab induction followed by belatacept/rapamycin maintenance regimen show significantly higher percentages of T_Naïve cells in both CD4⁺ and CD8⁺ compartments, with a significantly lower frequency of CD8⁺ T_EM cells when compared with a cohort treated with basiliximab induction and standard care maintenance regimen. (*p ≤ 0.05; ** p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001)

(A) CD4⁺ T cells to increase frequency of T_Naïve cells and reduce the frequency of T_EM cells during repopulation; however, this did not reach statistical significance when compared with baseline proportions. In contrast, CD8⁺ reconstitution contained increased in T_Naïve and decreased in T_EM and T_EMRA cell percentages. (B) Patients treated with alemtuzumab induction followed by belatacept/rapamycin maintenance regimen show significantly higher percentages of T_Naïve cells in both CD4⁺ and CD8⁺ compartments, with a significantly lower frequency of CD8⁺ T_EM cells when compared with a cohort treated with basiliximab induction and standard care maintenance regimen. (*p ≤ 0.05; ** p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001)