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. 2016 Apr 6;9:37. doi: 10.1186/s13041-016-0217-3

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© Naganos et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Adenylyl cyclase-dependent cAMP synthesis is reduced in chico ¹ mutants. a Typical FRET images observed at the distal end of the α/α’ MB lobe 10 sec before (pre), and 60 sec after (post), forskolin stimulation in brains from control (UAS-Epac1-camps/+; OK107/+), chico ¹ (chico ¹ ; UAS-Epac1-camps/+; OK107/+) and MB-chico rescue (chico ¹ ,UAS-chico/chico ¹ ; UAS-Epac1-camps/+; OK107/+) flies. A shift towards red indicates an increased CFP/YFP ratio and increased cAMP amounts. Scale bar, 10 μm. b Time course of FRET changes (CFP/YFP) during forskolin stimulation. c Summary of maximum FRET changes (maximum CFP/YFP) upon forskolin stimulation. N = 14 for control lines, N = 13 for chico ¹ mutants and MB rescue lines. *** P < 0.001, and ** P < 0.01. Data are shown as means ± SEM