Table 1.
Subject demographics percentages are based on the total number of subjects with nonmissing values in relevant treatment group
| SAD study | MAD study | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Placebo | BAN2401 (mg/kg) | Placebo | BAN2401 (mg/kg) | |||||||||||
| (N = 12) | 0.1 (N = 6) | 0.3 (N = 6) | 1 (N = 6) | 3 (N = 6) | 10 (N = 6) | 15 (N = 6) | Total (N = 36) | (N = 8) | 0.3 (N = 6) | 1 (N = 6) | 3 (N = 6) | 10 (N = 6) | Total (N = 24) | |
| Age: mean year (SD) | 72.1 (9.2) | 70.0 (12.0) | 72.7 (6.5) | 75.0 (14.0) | 68.2 (8.4) | 68.7 (9.1) | 70.8 (11.5) | 70.9 (10.0) | 70.0 (11.70) | 69.0 (13.19) | 69.0 (6.99) | 71.8 (11.48) | 70.3 (9.81) | 70.0 (9.97) |
| Female gender, n (%) | 5 (41.7) | 4 (66.7) | 2 (33.3) | 2 (33.3) | 3 (50.0) | 2 (33.3) | 5 (83.3) | 18 (50.0) | 2 (25.0) | 2 (33.3) | 5 (83.3) | 4 (66.7) | 2 (33.3) | 13 (54.2) |
| MMSE (mean) | 23.5 | 25.2 | 24.7 | 23.5 | 24.0 | 24.2 | 21.5 | 23.8 | 24.1 | 24.0 | 21.7 | 23.7 | 23.8 | 23.3 |
MMSE Mini Mental State Examination, SAD single ascending dose, MAD multiple ascending dose