Table 5.
CSF and corresponding serum concentrations and CSF: serum ratios
| BAN2401 levels 24 h after final dose | BAN2401 levels 10-14 days after final dose | |||||
|---|---|---|---|---|---|---|
| Cohort (dose mg/kg) | CSF (ng/mL) | Serum (μg/mL) | CSF:serum Ratio | CSF (ng/mL) | Serum (μg/mL) | CSF:serum ratio |
| SAD6 (15) | 96.3 (45.1) | 265 (63.1) | 0.04 % (0.03 %) | 72.2, 624a | 104 (31.3) | 0.07 %, 0.81%a |
| MAD1 (0.3) | 3.47 (2.1) | 4.85 (1.3) | 0.08 % (0.05 %) | CSF not collected | ||
| MAD2 (1) | 8.89 (5.31) | 17.6 (1.05) | 0.04 % (0.03 %) | |||
| MAD3 (3) | 25.0 (13.3) | 44.1 (4.55) | 0.06 % (0.04 %) | |||
| MAD4 (10) | 263 (106) | 211 (46.0) | 0.13 % (0.03 %) | 116 (109) | 37.5 (21.8) | 0.29 % (0.14 %) |
Values are expressed as mean and (SD)
CSF cerebrospinal fluid, SAD single ascending dose, MAD multiple ascending dose
aIndividual values are shown because n = 2