Additional file 10: Movie M1.

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Assembly of adenosine A₁ and A_2A receptors in complex with two G proteins and MD simulation of the system. The assembly of G_s and G_i bound to the adenosine A₁R-A_2AR heterotetramer was subjected to 500 ns of MD simulation in a rectangular box containing the system, the lipid bilayer, explicit solvent, and ions. A₁R protomers are in orange and red, A_2AR protomers in light and dark green, G_α in white, G_β in gray, and G_γ in purple. For easier visualization of protomer-protomer interfaces, TMs 4 and 5 are highlighted in blue and white, respectively. (MPEG 87870 kb)