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. 2016 Apr 6;7:133. doi: 10.3389/fimmu.2016.00133

Figure 5.

Figure 5

Enhanced dilution of CFSE by perforin-deficient NK cells following MCMV infection in Prf1−/−/C57BL/6 chimeric mice. (A) A 1:1 mixture of C57BL/6 (CD45.1+) and Prf1−/− (CD45.2+) CSFE-labeled splenocytes were adoptively transferred to CD45.1 × CD45.2 mice that were infected with MCMV 3 h prior to transfer. (B) Ratio of number of adoptively transferred Prf1−/− and C57BL/6 NK cells is depicted. (C) Proliferation of adoptively transferred Prf1−/− and C57BL/6 NK cells in spleen was determined by analyzing CFSE dilution on day 5 p.i. Representative histograms for mock and MCMV-infected mice (left), and quantification of CFSE− NK cells (right) are shown. Asterisks denote significant values: *P < 0.05; **P < 0.01; ***P < 0.001.