TABLE 1.
Summary of FTLD-TDP and ALS/MND-TDP Cases
| Case ID | Sex | Age | PMI, h | Gene | TDP-43 DG NCIs | TDP-43 DG NIIs | Neuropath Diagnosis |
|---|---|---|---|---|---|---|---|
| F1 | M | 74 | 30.9 | GRN | + | 0 | FTLD-TDP-A |
| F2 | F | 73 | 20.7 | None | + | 0 | FTLD-TDP-A |
| F3 | M | 64 | 2.3 | C9ORF72 | ++ | 0 | FTLD-TDP-A; argyrophilic grain disease |
| F4 | M | 72 | 23.8 | None | ++ | 1 | FTLD-TDP-A |
| F5 | M | 70 | 34.4 | C9ORF72 | ++ | 0 | FTLD-TDP-A |
| F6 | F | 66 | 7.4 | GRN | + | 0 | FTLD-TDP-A |
| F7 | M | 68 | 7.5 | C9ORF72 | ++ | 0 | FTLD-TDP-B; ALS/MND |
| F8 | M | 71 | 11.5 | C9ORF72 | ++ | 0 | FTLD-TDP-B; ALS/MND |
| F9 | F | 62 | 42.3 | None | +++ | 0 | FTLD-TDP-B; ALS/MND |
| F10 | M | 66 | 12.1 | None | ++ | 0 | FTLD-TDP-B; ALS/MND |
| F11 | M | 66 | 18.5 | None | + | 0 | FTLD-TDP-B; ALS/MND |
| F12 | M | 48 | 21 | C9ORF72 | ++ | 0 | FTLD-TDP-B |
| F13 | M | 62 | 28 | None | + | 0 | FTLD-TDP-C |
| F14 | F | 72 | 6.1 | None | +++ | 0 | FTLD-TDP-C |
| F15 | F | 76 | 17.1 | None | + | 0 | FTLD-TDP-C |
| F16 | M | 65 | 14.3 | None | ++ | 0 | FTLD-TDP-C |
| F17 | F | 69 | 10.7 | None | ++ | 0 | FTLD-TDP-C |
| F18 | M | 74 | 3.3 | None | ++ | 0 | FTLD-TDP-C |
| F19 | M | 70 | 13.2 | None | ++ | 0 | FTLD-TDP-C |
| F20 | M | 66 | 10 | None | + | 0 | FTLD-TDP-C |
| F21 | F | 71 | 7.3 | None | ++ | 0 | FTLD-TDP-C |
| F22 | F | 72 | 13.5 | None | +++ | 0 | FTLD-TDP-C |
| F23 | F | 52 | 20 | None | + | 0 | FTLD-TDP-C |
| F24 | F | 83 | NA | None | +++ | 0 | FTLD-TDP-C |
| F25 | M | 47 | NA | VCP | + | 0 | FTLD-TDP-D; ALS/MND |
| A1 | M | 69 | 51 | NA | + | 0 | ALS/MND-TDP subtype unspecified |
| A2 | M | 62 | NA | NA | + | 0 | ALS/MND-TDP subtype unspecified |
0 = none; + = rare; ++ = moderate; +++ = frequent.
ALS = amyotrophic lateral sclerosis; DG = dentate gyrus; F = female; FTLD = frontotemporal lobar degeneration; M = male; MND = motor neuron disease; NA = not available; NCI = neuronal cytoplasmic inclusion; NII = neuronal intranuclear inclusion; PMI = postmortem interval.