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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: J Pharm Sci. 2015 Jul 6;104(10):3426–3439. doi: 10.1002/jps.24551

Table 2.

A: Stability of SAMT analogues in aqueous solution at pH 4.0. Data represent N=3 (mean ± SD) or N=2 (mean). (ND – Not Detected)
Time (weeks) SAMT-08
(pmol/µL)
 SAMT-10
(pmol/µL)
 SAMT-19
(pmol/µL)
 SAMT-247
(pmol/µL)
0 46.5 ± 0.1 53.6 79.4 82
1 40.9 ± 0.1 40.4 ± 1 5.6 40.3 ± 1.5
2 35.1 ± 0.5 32.1 ± 0.5 0.7 23.5 ± 2
4 26.8 ± 0.2 20.5 ± 0.7 ND 8.0 ± 0.6
Degradation
rate constant
(k) (10−7 sec−1)		 2.3 5.0 46.1 9.2
B: Stability of SAMT analogues in aqueous solution at pH 5.0. Data represent N=3 (mean ± SD) or N=2 (mean). (ND – Not Detected)
Time (weeks) SAMT-08
(pmol/µL)
 SAMT-10
(pmol/µL)
 SAMT-19
(pmol/µL)
 SAMT-247
(pmol/µL)
0 68.6 ± 0.2 53 82.5 79
1 57.3 ± 0.6 37.5 6.1 ± 0.03 36 ± 2.2
2 49.0 ± 1.8 28.1 0.7 ± 0.16 18.4 ± 0.8
4 36 ± 1.43 15.8 ND 6.2 ± 0.5
Degradation
rate constant
(k) (10−7 sec−1)		 2.3 5.0 46.06 11.51