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SPR inhibits EBV capsid formation. AGSiZ cells were induced to permit EBV replication with doxycycline and treated with 10 μM SPR (+S) or vehicle alone (–S). The cells were harvested, fixed at 4 d postinduction, and analyzed by electron microscopy. Viral particles were seen in vehicle-treated cells (–S) as shown in magnifications of 1,500× and 5,000× . No viral particles were detectable in the SPR-treated samples (+S).
