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Mineralocorticoid antagonist assay of SPR and congeners. Aldosterone blocking assay was performed by addition of aldosterone and serial dilutions of each antagonist (SPR, EPR, CAN, and TMS) to cells carrying a mineralocorticoid receptor-driven luciferase gene. Luciferase activity was measured 24 h after drug treatment and expressed as relative light units (RLUs). The concentration of each drug is shown on the x axis.
