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Sequence alignment of human F-box domains. Ubv binding region was defined by alignment to Fbw7 residues that fall within 10 Å of Ubv.Fw7.1 in the structure of Skp1tr–Fbw7F-box–Ubv.Fw7.1 complex. Sequences were clustered according to sequence identity in the Ubv binding region using average distance method. Fbw7 and Fbw11 are highlighted by red boxes.
